ISSN: 1300 - 6525 E-ISSN: 2149 - 0880
kulak burun boğaz
ve baş boyun cerrahisi dergisi
http://dergi.kbb-bbc.org.tr
Koşulsuz Destek Verenler

Kayıtlı İndeksler









Modifiye Sistemik İnflamasyon Skoru, İndetermine Tiroid Nodüllerinde Malignitenin Bir Göstergesi midir?
Is Modified Systemic Inflammation Score a Predictor of Malignancy in Indeterminate Thyroid Nodules?
Received Date : 03 Jan 2023
Accepted Date : 20 Feb 2023
Available Online : 23 Feb 2023
aDepartment of Otolaryngology, Ümraniye Training and Research Hospital University of Health Sciences, İstanbul, Türkiye bDepartment of Otolaryngology, Vrije Universiteit, Brussel, Belgium cClinic of Otorhinolaryngology, Acıbadem Ataşehir Hospital, İstanbul, Türkiye dPrivate Physician, İstanbul, Türkiye eDepartment of Otolaryngology, University of Health Sciences Sancaktepe Martyr Prof Dr İlhan Varank Training and Research Hospital, İstanbul, Türkiye fClinic of Otorhinolaryngology, Private Sancaktepe Bölge Hospital, İstanbul, Türkiye gDepartment of Pathology, University of Health Sciences Ümraniye Training and Research Hospital, İstanbul, Türkiye
Doi: 10.24179/kbbbbc.2023-95264 - Makale Dili: EN
KBB ve BBC Dergisi. 2023;31(2):109-14
ÖZET
Amaç: Bu çalışmanın amacı belirsiz tiroid nodülü olan hastalarda malignite varlığını öngörmede modifiye sistemik inflamasyon skorunun (mSIS) preoperatif tanısal değerini araştırmaktır. Gereç-Yöntem: Retrospektif bir çalışmadır. Tiroid lobektomi yapılan 368 hasta tarandı. Modifiye SIS'e göre hastalar 3 gruba ayrıldı; Albümin (Alb) ≥ 4,0 gr/dL ve Lenfosit Monosit Oranı (LMR) ≥ 3,4 olanlar mSIS 0, Alb <4,0 gr/dL veya LMR <3,4 olanlar mSIS 1, Alb <4,0 gr/dL ve LMR<3.4 olanlar mSIS 2. Postoperatif patoloji sonuçlarına göre hastalar benign ve malign olarak iki gruba ayrıldı. Bulgular: Histopatolojik incelemede 24 hastada malignite saptandı. Bunların 10'u (%41,7) mikropapiller, 8'i (%33,3) papiller ve 6'sı (%25) foliküler karsinomdu. Malign ve benign gruplar arasında LMR ve Albümin değerleri açısından fark yoktu. mSIS 0'da malignite oranı %65, mSIS 1'de %69,2 ve mSIS 2'de %66,6 idi. Gruplar arasında istatistiksel olarak anlamlı fark yoktu. Sonuç: MSIS, indetermine tiroid nodüllerinde malignitenin bir göstergesi olmayabilir. Bu konuyu anlamak için daha ileri çalışmalara ihtiyaç vardır.
ABSTRACT
Objective: The aim of this study is to evaluate the preoperative diagnostic value of modified systemic inflammation score (mSIS) in predicting the presence of malignancy in patients with indeterminate thyroid nodules. Matherials and Methods: It is a retrospective study. 368 patients who underwent thyroid lobectomy were screened. Patients were divided into 3 groups according to modified SIS; mSIS 0 for those were Albumin (Alb) ≥ 4.0 gr/dL and Lymphocyte Monocyte Ratio (LMR) ≥ 3.4 , mSIS 1 for those were Alb<4.0 gr/dL or LMR<3.4, mSIS 2 for those were Alb<4.0 gr/dL and LMR<3.4. According to the results of the postoperative pathology, the patients were divided into two groups as benign and malignant. Results: The malignancy was found in 24 patients in histopathological examination. 10 (41.7%) of these were micropapillary, 8 (33.3%) were papillary and 6 (25%) were follicular carcinomas. There was no difference between the malignant and benign groups in terms of LMR and Albumin values. mSIS 0 had a 65% malignancy rate, mSIS 1 69.2%, and mSIS 2 66.6%. There was no statistically significant difference between the groups. Conclusion: MSIS may not be a predictor of malignancy in indeterminate thyroid nodules. Further studies are needed to understand this issue.