ORIGINAL RESEARCH
Can We Use Neutrophil: Lymphocyte Ratio, Platelet: Lymphocyte Ratio, and Systemic Immune-Inflammation Index Values to Differentiate Larynx Carcinoma from Benign and Premalignant Laryngeal Diseases in the Elderly?
Yaşlılarda Laringeal Skuamoz Hücreli Karsinomla Benign ve Premalign Laringeal Hastalıkların Ayrımında Nötrofil: Lenfosit Oranı, Trombosit: Lenfosit Oranı ve Sistemik İmmün-İnflamasyon İndeksi Değerlerini Kullanabilir miyiz?
Received Date : 22 Feb 2021
Accepted Date : 14 Mar 2021
Available Online : 18 Mar 2021
Mehmet Emre SİVRİCEa, Yusuf Çağdaş KUMBULa, Hasan YASANa, Mustafa TÜZa,
Erdoğan OKURa, Vural AKINa
aDepartment of Oto-Rhino-Laryngology and Head&Neck Surgery, Süleyman Demirel University Faculty of Medicine, Isparta, TURKEY
Doi: 10.24179/kbbbbc.2021-82505 - Makale Dili: EN
KBB ve BBC Dergisi. 2021;29(3):185-9
Copyright © 2020 by Turkey Association of Society of Ear Nose Throat and Head Neck Surgery. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Objective: Timing for laryngeal biopsy is challenging
for geriatric patients due to their comorbidities and anesthetic risks.
The aim of this study is to find an indicator that would both allow surgeons
to predict the need for laryngeal biopsy, and to diagnose the malignancy
at an early stage. Material and Methods: This is a
retrospective cohort study of 103 participants. Three groups were constituted
according to the results of laryngeal biopsy (benign-Group 1,
premalignant-Group 2, and malignant-Group 3). The neutrophil:
lymphocyte ratio, the platelet: lymphocyte ratio, and the systemic immune-
inflammation index (neutrophil count × platelet count) /
lymphocyte count) values of the three groups were compared between
groups. Results: The male: female ratio was 100:3, and the mean age
was 70.87 (±6.38) years, with no significant differences among the
three groups [Group 1: 70.40 (±5.94), Group 2: 70.44 (±5.09), Group
3: 71.15 (±6.91)] (p=0.88). There were no statistically significant differences
among the three groups in neutrophil: lymphocyte ratio
(p=0.84), platelet: lymphocyte ratio (p=0.36), or systemic immune-inflammation
index values (p=0.67). Conclusion: Indices calculated from
haematological parameters and showing systemic inflammation may
not be reliable in the geriatric population due to immunosenescence.
For this reason, indices calculated from haematological parameters should
be studied distinctly in the geriatric population without including
other age groups. Other methods are needed to help predict the timing
of laryngeal biopsy in geriatric patients.
Keywords: Aged; carcinoma; squamous cell; larynx; inflammation; immunosenescence
ÖZET
Amaç: Laringeal biyopsi için zamanlamanın planlanması, komorbiditeleri
ve anestezi riskleri nedeniyle geriatrik hastalar için zordur.
Bu çalışmanın amacı, hem laringeal biyopsi ihtiyacını tahmin
etmemize hem de maligniteyi erken dönemde teşhis etmemize olanak
sağlayacak bir indeks tespit etmektir. Gereç ve Yöntemler: Bu
çalışma, 103 hastayı içeren retrospektif bir kohort çalışmasıdır.
Laringeal biyopsi sonuçlarına göre 3 grup oluşturuldu (benign-Grup 1,
premalign-Grup 2 ve malign-Grup 3). Üç grubun nötrofil: lenfosit
oranı, trombosit: lenfosit oranı ve sistemik immün-inflamasyon indeksi
(nötrofil sayısı × platelet sayısı)/lenfosit sayısı) değerleri karşılaştırıldı.
Bulgular: Çalışma grubunun erkek: kadın oranı 100: 3 ve ortalama yaşı
70.87 (±6.38) yıl olup, gruplar kıyaslandığında anlamlı bir fark yoktu
[Grup 1: 70.40 (±5.94), Grup 2: 70.44 (±5.09), Grup 3: 71.15 (±6.91)]
(p=0.88). Üç grup arasında nötrofil: lenfosit oranı (p=0.84), trombosit:
lenfosit oranı (p=0.36) ve sistemik immün-inflamasyon indeksi
değerleri (p=0.67) arasında istatistiksel olarak anlamlı fark yoktu.
Sonuç: Hematolojik parametrelerden hesaplanan ve sistemik inflamasyonu
gösteren indeksler immün yaşlanma nedeniyle geriatrik
popülasyonda güvenilir olmayabilir. Bu nedenle hematolojik parametrelerden
hesaplanan indeksler, geriatrik popülasyonda diğer yaş
grupları dâhil edilmeden çalışılmalıdır. Geriatrik hastalarda, laringeal
biyopsinin zamanlamasını tahmin etmeye yardımcı olmak için başka
yöntemlere ihtiyaç vardır.
Anahtar Kelimeler: Yaşlı; karsinom; skuamöz hücre; larinks; inflamasyon; immün yaşlanma
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