Objective: To objectively document the efficacy of mometasone furoate nasal spray (MFNS) in the treatment of sinonasal polyposis (SNP). Material and Methods: The study was designed prospectively in a group of patients with SNP and negative history of surgery. Ten patients were administered MFNS 100 mcg to each nostril once a day for eight weeks. All patients underwent Tc-99m MAA (macroaggregated albumin) rhinoscintigraphic evaluation of mucociliary activity and endoscopic evaluation before and after the treatments. Response to treatment, in terms of rhinoscintigraphic and endoscopic improvement, was assessed. Results: Of the 10 patients 8 were male and 2 female, with an average age of 45 years (24-61). Following treatment, mucociliary transport time was significantly reduced (p< 0.05) and the polyps were clinically shrunk (p<0.05). Conclusion: It was determined that MFNS treatment was effective in the treatment of SNP. Mometasone furoate (MF) can be considered, as an alternative to other topical steroids, in the treatment of SNP.

Amaç: “Mometasone furoate” burun spreyi (MFNS)’nin, sinonazal polipozis (SNP)’in tedavisindeki etkisini objektif olarak ortaya koymak. Gereç ve Yöntemler: Çalışma SNP’li ve cerrahi geçirmemiş bir grup hastada prospektif olarak planlandı. MFNS, 10 hastanın her bir burun deliğine 100 mcg günde bir kez sekiz hafta uygulanmıştır. Tüm hastalar için, tedavi öncesi ve sonrası, endoskopik değerlendirme ve Tc-99mMAA(“macroaggregated” albumin) rinosintigrafi ile mukosilier transport zamanı değerlendirmesi yapıldı. Tedaviye cevap, rinosintigrafik ve endoskopik düzelme ile değerlendirildi. Bulgular: Hastalardan 8’i erkek, 2’si bayan, ortalama yaş 45 (24-61) idi. Tedaviyi takiben mukosilier transport zamanı anlamlı derecede azaldı (p< 0.05) ve polipler anlamlı derecede küçüldü (p< 0.05). Sonuç: MFNS, SNP’in tedavisinde efektiftir. “Mometasone furoate” (MF), SNP’in tedavisinde diğer topikal steroidlere bir alternatif olarak düşünülebilir.