ORIGINAL RESEARCH
Comparison of Neutrophil Lymphocyte Ratio in Benign, Premalignant and Malignant Laryngeal Lesions
Benign, Premalign ve Malign Laringeal Lezyonlarda Nötrofil Lenfosit Oranının Karşılaştırılması
Received Date : 24 May 2021
Accepted Date : 09 Nov 2021
Available Online : 16 Oct 2021
Mustafa ÇOLAKa, Ali Rıza YAĞMURa, Şeyda AKBAL ÇUFALIa, Nagihan GÜLHAN YAŞARa, Aykut İKİNCİOĞULLARIa, Hacı Hüseyin DEREa
aClinic of Otolaryngology, Ankara City Hospital, Ankara, TURKEY
Doi: 10.24179/kbbbbc.2021-84615 - Makale Dili: EN
KBB ve BBC Dergisi. 2022;30(1):1-6
Copyright © 2020 by Turkey Association of Society of Ear Nose Throat and Head Neck Surgery. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Objective: Benign (BG), premalignant (PG) and malignant
(MG) lesions can be seen in the laryngeal mucosa. Histopathological
examination is absolutely necessary to differentiate these
lesions. The ability to differentiate these lesions with inexpensive, easily
applicable biomarkers before biopsy can contribute to the planning
of the patient’s treatment. The aim of this study is to examine whether
neutrophil lymphocyte ratio (NLR) can be used as a biomarker to differentiate
MG laryngeal lesions from BG laryngeal lesion and PG laryngeal
lesion. Material and Methods: This retrospective study was
performed on 72 patients who underwent biopsy to determine their
histopathological diagnosis for laryngeal lesions. We analyzed the patient
files for clinical, histopathological and laboratory data. The patients
were divided into three groups as BG, PG and MG groups
according to their histopathological findings. Groups were compared
in terms of NLR and other laboratory data. Results: The mean NLR
was 2.22±0.61, 2.57±0.8, 3.14±0.91 in the BG, PG and MG, respectively
(p=0.001). NLR was higher in MG than BG (p<0.001). NLR values
between BG-PG and PG-MG were similar. Conclusion: NLR is
higher in MG laryngeal lesions than BG laryngeal lesions. However,
NLR is not different from BG and MG lesions in PG laryngeal lesions.
Keywords: Laryngeal carcinoma; benign laryngeal lesions; premalignant laryngeal lesions; neutrophil lymphocyte ratio
ÖZET
Amaç: Laringeal mukozada benign (BG), premalign (PG) ve
malign (MG) lezyonlar görülebilir. Bu lezyonların ayrımında mutlaka
histopatolojik inceleme gereklidir. Biyopsi öncesinde bu lezyonların
ucuz, kolay uygulanabilir biyobelirteçlerle ayırt edilebilmesi, hastanın
tedavisinin planlanmasına katkıda bulunabilir. Bu çalışmanın amacı,
nötrofil lenfosit oranının (NLO) MG laringeal lezyonları, BG laringeal
lezyonlardan ve PG laringeal lezyonlardan ayırt etmek için bir biyobelirteç
olarak kullanılıp kullanılamayacağını incelemektir. Gereç ve
Yöntemler: Bu retrospektif çalışma, larenks lezyonlarının histopatolojik
tanısını belirlemek için biyopsi yapılan 72 hasta üzerinde gerçekleştirildi.
Hasta dosyaları klinik, histopatolojik ve laboratuvar verileri
için analiz edildi. Hastalar histopatolojik bulgularına göre BG, PG ve
MG olarak 3 gruba ayrıldı. Gruplar NLO ve diğer laboratuvar verileri
açısından karşılaştırıldı. Bulgular: Ortalama NLO, BG, PG ve MG’de
sırasıyla 2,22±0,61, 2,57±0,8, 3,14±0,91 idi (p=0,001). MG’de NLO,
BG’den daha yüksekti (p<0,001). BG-PG ve PG-MG arasındaki NLO
değerleri benzerdi. Sonuç: NLO, MG laringeal lezyonlarda BG laringeal
lezyonlardan daha yüksektir. Ancak NLO, PG laringeal lezyonlarda
BG ve MG lezyonlardan farklı değildir.
Anahtar Kelimeler: Larinks kanseri; benign larinks lezyonları; premalign larinks lezyonları; nötrofil lenfosit oranı
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