ORIGINAL RESEARCH
Does Preoperative Vitamin K Injection Prevent the Bleeding Tendency in Adenoidectomy?
Preoperatif K Vitamini Enjeksiyonu Adenoidektomide Kanama Eğilimini Önler mi?
Received Date : 29 Apr 2020
Accepted Date : 14 May 2020
Available Online : 11 Feb 2020
Oğuzhan DİKİCİa, Fevzi SOLMAZa, Osman DURGUTa
aDepartment of Otorhinolaryngology, Health Sciences University of Bursa, Yüksek İhtisas Training and Research Hospital, Bursa, TURKEY
Doi: 10.24179/kbbbbc.2020-75769 - Makale Dili: EN
KBB ve BBC Dergisi. 2021;29(1):1-5
Copyright © 2020 by Turkey Association of Society of Ear Nose Throat and Head Neck Surgery. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Objective: To investigate the effectiveness of preoperative
vitamin K injection for hemostasis in adenoidectomy. Material and
Methods: A total of 42 patients were included in the study. Vitamin K
was injected to 21 of the patients preoperatively. The amount of intraoperative
bleeding was classified as mild, moderate or severe. The adenoidectomy
operation time was recorded. All patients were evaluated
with complete blood count, activated partial thromboplastin time, prothrombin
time, and bleeding time, both before surgery and on the morning
of the first postoperative day. The differences between preoperative
and postoperative measurements were calculated. Results: The amount
of intraoperative bleeding was severe in 2 (9.5%) patients in the control
group and 1 (4.8%) patient in the vitamin K group. The mean adenoidectomy
operation time was 8.09±3.49 minutes in the control group
and 7.76±2.80 minutes in the vitamin K group. The difference between
preoperative and postoperative hemoglobin values was significantly
lower in the vitamin K group than the control group (p<0.05). There was
a statistically significant positive relationship between the operation time,
the amount of intraoperative bleeding, and age in both groups (p<0.05).
Conclusion: The present study has demonstrated that preoperative vitamin
K injections helped prevent bleeding during adenoidectomy.
Keywords: Vitamin K; adenoidectomy; hemostasis; hemorrhage
ÖZET
Amaç: Adenoidektomide hemostaz için preoperatif K vitamini
enjeksiyonunun etkinliğini araştırmaktır. Gereç ve Yöntemler: Çalışmaya,
toplam 42 hasta dâhil edildi. Ameliyat öncesi 21 hastaya K vitamini
enjekte edildi. İntraoperatif kanama miktarı hafif, orta veya
şiddetli olarak sınıflandırıldı. Adenoidektomi operasyon süresi kaydedildi.
Tüm hastalar hem ameliyattan önce hem de ameliyat sonrasındaki
ilk sabah tam kan sayımı, aktive parsiyel tromboplastin zamanı,
protrombin zamanı ve kanama zamanıyla değerlendirildi. Ameliyat öncesi
ve sonrası ölçümler arasındaki farklar hesaplandı. Bulgular: İntraoperatif
kanama miktarı kontrol grubunda 2 (%9,5) hastada ve K
vitamini grubunda 1 (%4,8) hastada şiddetli idi. Ortalama adenoidektomi
operasyonu süresi kontrol grubunda 8,09±3,49 dk ve K vitamini
grubunda 7,76±2,80 dk idi. Preoperatif ve postoperatif hemoglobin değerleri
arasındaki fark K vitamini grubunda kontrol grubuna göre anlamlı
olarak düşüktü (p<0,05). Her 2 grupta ameliyat süresi,
intraoperatif kanama miktarı ve yaş arasında istatistiksel olarak anlamlı
bir ilişki vardı (p<0,05). Sonuç: Bu çalışma, preoperatif K vitamini enjeksiyonlarının
adenoidektomi sırasında kanamayı önlemeye yardımcı
olduğunu göstermiştir.
Anahtar Kelimeler: Vitamin K; adenoidektomi; hemostazis; kanama
KAYNAKLAR
- Lepcha A, Kurien M, Job A, Jeyaseelan L, Thomas K. Chronic adenoid hypertrophy in children-is steroid nasal spray beneficial? Indian J Otolaryngol Head Neck Surg. 2002;54(4):280-4.[PubMed]
- Kay DJ, Mehta V, Goldsmith AJ. Perioperative adenotonsillectomy management in children: current practices. Laryngoscope. 2003;113(4):592-7.[Crossref] [PubMed]
- Clemens J, McMurray JS, Willging JP. Electrocautery versus curette adenoidectomy: comparison of postoperative results. Int J Pediatr Otorhinolaryngol. 1998;1;43(2):115-22.[Crossref] [PubMed]
- Jo SH, Mathiasen RA, Gurushanthaiah D. Prospective, randomized, controlled trial of a hemostatic sealant in children undergoing adenotonsillectomy. Otolaryngol Head Neck Surg. 2007;137(3):454-8.[Crossref] [PubMed]
- Newman P, Shearer MJ. Vitamin K metabolism. Fat-Soluble Vitamins: Springer; 1998. p.455-88.[Crossref] [PubMed]
- Shearer MJ. Vitamin K deficiency bleeding (VKDB) in early infancy. Blood Rev. 2009;23(2):49-59.[Crossref] [PubMed]
- Suttie JW. Vitamin K and human nutrition. J Am Diet Assoc. 1992;92(5):585-90.[PubMed]
- Aziz F, Patil P. Role of prophylactic Vitamin K in preventing antibiotic induced hypoprothrombinemia. Indian J Pediatr. 2015;82(4):363-7.[Crossref] [PubMed]
- Mathiasen RA, Cruz RM. Prospective, randomized, controlled clinical trial of a novel matrix hemostatic sealant in children undergoing adenoidectomy. Otolaryngol Head Neck Surg. 2004;131(5):601-5.[Crossref] [PubMed]
- Yasar H, Ozkul H. Haemostatic effect of Ankaferd Blood Stopper® seen during adenoidectomy. Afr J Tradit Complement Altern Med. 2011;8(4):444-6.[Crossref] [PubMed] [PMC]
- Windfuhr JP, Chen YS. Post-tonsillectomy and-adenoidectomy hemorrhage in nonselected patients. Ann Otol Rhinol Laryngol. 2003;112(1):63-70.[Crossref] [PubMed]
- Demirbilek N, Evren C, Altun U. Postadenoidectomy hemorrhage: how we do it? Int J Clin Exp Med. 2015;8(2):2799-803.[PubMed]
- Warad D, Hussain FTN, Rao AN, Cofer SA, Rodriguez V. Haemorrhagic complications with adenotonsillectomy in children and young adults with bleeding disorders. Haemophilia. 2015;21(3):e151-5.[Crossref] [PubMed]
- Dam H, Dyggve H, Larsen H, Plum P. The relation of vitamin K deficiency to hemorrhagic disease of the newborn. Adv Pediatr. 1952;5:129-53.[PubMed]
- Conly JM, Ramotar K, Chubb H, Bow EJ, Louie TJ. Hypoprothrombinemia in febrile, neutropenic patients with cancer: association with antimicrobial suppression of intestinal microflora. J Infect Dis. 1984;150(2):202-12.[Crossref] [PubMed]
- Zagólski O. [Post-tonsillectomy haemorrhage--do coagulation tests and coagulopathy history have predictive value?]. Acta Otorrinolaringol Esp. 2010;61(4):287-92.[Crossref] [PubMed]
