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ORIGINAL RESEARCH

Hematological Markers in Idiopathic Chronic Otitis Media with Effusion in Adults
Erişkinlerde İdiyopatik Kronik Efüzyonlu Otitis Media Hastalığında Hematolojik Belirteçler
Received Date : 06 Jul 2022
Accepted Date : 12 Sep 2022
Available Online : 15 Sep 2022
Doi: 10.24179/kbbbbc.2022-92454 - Makale Dili: TR
KBB ve BBC Dergisi. 2023;31(1):1-6
Copyright © 2020 by Turkey Association of Society of Ear Nose Throat and Head Neck Surgery. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Objective: It is not known whether hematological inflammatory markers, which have been used in the follow-up of many diseases in recent years, are affected in otitis media with effusion (OME). The aim of this study was to determine the role of the inflammatory event in the etiopathogenesis of the OME in adult with hematological inflammatory markers such as neutrophil-lymphocyte ratio (NLR), eosinophil-lymphocyte ratio (ELO) and basophil-lymphocyte ratio (BLR), and the clinical significance of these markers. Material and Methods: In this study, patients diagnosed with chronic OME and applied ventilation tube insertion were retrospectively screened. Twenty five patients between the ages of 18-65 who were diagnosed with unilateral or bilateral chronic OME without any other health problems constituted the study group. The control group was consisted of 25 healthy and drug-free individuals aged 18-65 years. Hematological, demographic and audiological datas were obtained from medical records. Results: The mean NLR values of the patients in the study and control groups were respectively 2.14±1.08 and 1.52±0.42, mean ELR values were 0.077±0.041 and 0.062±0.040, and mean BLR values were 0.041±0.024 and 0.030±0.012 (p=0.004, p=0.188 and p=0.152, respectively). The mean NLR values of the of the patients in the reccuring and non-reccuring groups were respectively 2.00±0.65 and 2.22±1.24, mean ELR values were 0.062±0.043 and 0.084±0.039, and mean BLR values were 0.031±0.009 and 0.045±0.028 (p=0.137, p=0.950 and p=0.175, respectively). Conclusion: The significantly high NLR indicates that an inflammatory event occurs in the etiopathogenesis of idiopathic chronic OME disease in adults.
ÖZET
Amaç: Son yıllarda birçok hastalığın takibinde kullanılan hematolojik inflamatuar belirteçlerin efüzyonlu otitis media (EOM) hastalığında etkilenip etkilenmediği bilinmemektedir. Bu çalışmanın amacı, erişkinlerde EOM hastalığında nötrofil-lenfosit oranı (NLO), eozinofil-lenfosit oranı (ELO) ve bazofil-lenfosit oranı (BLO) gibi hematolojik inflamatuar belirteçler ile hastalığın etiyopatogenezinde inflamatuar olayın rolünü araştırmak ve bu belirteçlerin klinik önemini belirlemektir. Gereç ve Yöntemler: Bu çalışmada, kronik EOM tanısı alıp ventilasyon tüpü takılan hastalar retrospektif olarak tarandı ve 18- 65 yaş aralığında tek taraflı veya çift taraflı kronik EOM tanısı alan başka bir sağlık sorunu olmayan 25 hasta çalışma grubunu oluşturdu. Kontrol grubunu ise 18-65 yaşlarında tamamen sağlıklı ve ilaç kullanmayan 25 birey oluşturdu. Hematolojik, demografik ve odyolojik veriler hasta dosyaları ve hastane bilgi yönetim sisteminden temin edildi. Bulgular: Çalışma ve kontrol grubunda hastaların sırasıyla ortalama NLO değerleri 2,14±1,08 ve 1,52±0,42, ortalama ELO değerleri 0,077±0,041 ve 0,062±0,040, ortalama BLO değerleri ise 0,041±0,024 ve 0,030±0,012 olarak bulundu (sırasıyla p=0,004, p=0,188 ve p=0,152). Nüks eden ve etmeyen hasta grubunda sırasıyla ortalama NLO değerleri 2,00±0,65 ve 2,22±1,24, ortalama ELO değerleri 0,062±0,043 ve 0,084±0,039, ortalama BLO değerleri ise 0,031±0,009 ve 0,045±0,028 olarak bulundu (sırasıyla p=0,137, p=0,950 ve p=0,175). Sonuç: NLO’nun anlamlı olarak yüksek bulunması, erişkinlerde idiyopatik kronik EOM hastalığının etiyopatogenezinde inflamatuar bir olayın gerçekleştiğini göstermektedir.
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