CASE REPORTS
Nasopharyngeal, Laryngeal and Tracheal Amyloidosis
Nazofarenks, Larenks ve Trakea Amiloidozu
Received Date : 06 Feb 2019
Accepted Date : 03 May 2019
İsmail GÜLERa, İhsan KUZUCUa, Deniz BAKLACIa, Esra UÇARYILMAZ ÖZHAMAMb
aKulak Burun Boğaz Hastalıkları Kliniği,
bPatoloji KliniÄŸi,
Ankara Numune Eğitim ve Araştırma Hastanesi, Ankara, TÜRKİYE
Doi: 10.24179/kbbbbc.2019-65384 - Makale Dili: TR
KBB ve BBC Dergisi 2019;27(2):80-4
Copyright © 2020 by Turkey Association of Society of Ear Nose Throat and Head Neck Surgery. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Amyloidosis is a rare, idiopathic disease and is characterised by the accumulation of
anormal extracellular protein. Amyloidosis can be hereditary or acquired, localised or systemic and
potentially lethal or appear as an incidental sign. Localised amyloidosis mostly occurs in the larynx
and lungs. Amyloidosis is rarely seen in the larynx. In this article, We present a patient who applied
to our clinic with symptoms of hoarseness and foreign body sensation in the throat and diagnosed
with nasopharyngeal, laryngeal and tracheal amyloidosis.
Keywords: Amyloidosis; nasopharynx; larynx; trachea
ÖZET
Amiloidoz; ekstraselüler fibriler protein depozitlerinin anormal birikimiyle karakterize,
nadir, idiyopatik bir hastalıktır. Amiloidoz; kalıtsal/kazanılmış, lokalize/sistemik, potansiyel ölümcül/
rastlantısal bir hastalık olarak karşımıza çıkabilmektedir. Lokalize amiloidozun en sık görüldüğü
yerler akciğerler ve larenkstir. Amiloidoz, larenkste nadir olarak karşımıza çıkmaktadır. Bu
çalışmada, boğazda ses kısıklığı ve yabancı cisim hissi şikâyetleri ile kliniğimize başvuran ve nazofarenks,
larenks ve trakea amiloidozu tanısı alan bir olgunun sunulması amaçlanmıştır.
Anahtar Kelimeler: Amiloidoz; nazofarenks; larenks; trakea
KAYNAKLAR
- Virchow R. Ueber eine im Gehirn und Rückenmark des Menschen aufgefundene Substanz mit der chemischen Reaction der Cellulose. Virchows Archiv. 1854;6(1):135-8. [Crossref]
- Napdalan V, Jones TM, Morar P, Clark AH, Jones AS. Localized amyloidosis of the paratoid gland: a case report an review of the localized amyloidosis of the head and neck. Head Neck. 1998;20(1):73-8. [Crossref]
- Satoskar AA, Burdge K, Cowden DJ, Nadasdy GM, Hebert LA, Nadasdy T. Typing amyloidosis in renal biopsies: diagnostic pitfalls. Arch Pathol Lab Med. 2007;131(6):917-22.
- Kumar V, Abbas AK, Fausto N, Aster JC. Diseases of theImmune System. In: Schmitt W, Gruliow R, eds. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia: Saunders Elsevier; 2010. p.249-55.
- Simpson GT 2nd, Strong MS, Skinner M, Chen AS. Localised amyloidosis of the head and neck and upper aerodigestive and lower respiratory tracts. Ann Otol Rhinol Laryngol. 1984;93(4 Pt 1):374-9. [Crossref] [PubMed]
- Hurbis CG, Holinger LD. Laryngeal amyloidosis in a child. Ann Otol Rhinol Laryngol. 1990;99(2 Pt 1):105-7. [Crossref]
- Mitrani M, Biller HF. Laryngeal amyloidosis. Laryngoscope. 1985;95(11):1346-7. [Crossref] [PubMed]
- Patel A, Pambuccian S, Maisel R. Nasopharygeal amyloidiosis Am J Otolaryngol. 2002;23(5):308-11. [Crossref] [PubMed]
- Chin SC, Fatterpeckar G, Kao CH, Chen CY, Som PM. Amyloidosis concurrently involving the sinonasal cavities and larynx. AJNR Am J Neuroradiol. 2004;25(4):636-8.
- Lewis JE, Olsen KD, Kurtin PJ, Kyle RA. Laryngeal amyloidosis: a clinopathologic and immunohistochemical review. Otolaryngol Head Neck Surg. 1992;106(4):372-7. [Crossref] [PubMed]
- Zhuang YL, Tsai TL, Lin CZ. Localized amyloid deposition in the nasopharynx and neck, mimicking nasopharyngeal carcinoma with neck metastasis. J Chin Med Assoc. 2005; 68(3):142-5. [Crossref]
- O'Halloran LR, Lusk RP. Amyloidosis of the larynx in a child. Ann Otol Rhinol Laryngol. 1994;108(8 Pt 1):590-4. [Crossref] [PubMed]
- Kyle RA, Bayrd ED. Amyloidosis: review of 236 cases. Medicine (Baltimore). 1975;54(4): 271-99. [Crossref] [PubMed]
- Gertz MA, Kyle RA. Primary systemic amyloidosis--a diagnostic primer. Mayo Clin Proc. 1989;64(12):1505-19. [Crossref]
- Piazza C, Cavaliere S, Foccoli P, Toninelli C, Bolzoni A, Peretti G. Endoscopic management of laryngo-tracheobronchial amyloidosis: a series of 32 patients. Eur Arch Otorhinolaryngol. 2003;260(7):349-54. [Crossref] [PubMed]
- Basut O, CoÅŸkun H, EriÅŸen L, Tezel Ä°, Onart S. [A case of layngeal amyloidosis]. Turk Arch Otolaryngol. 2003;41(3):164-8.