ORIGINAL RESEARCH
Prognostic Value of Whole Blood Viscosity in Sudden Sensorineural Hearing Loss
Ani Sensörinöral İşitme Kaybında Tam Kan Viskozitesinin Prognostik Değeri
Received Date : 09 Apr 2020
Accepted Date : 08 May 2020
Available Online : 23 Dec 2020
Doğukan ÖZDEMİRa, Nesrettin Fatih TURGUTa, Dursun Mehmet MEHELa, Mehmet ÇELEBİa, Abdulkadir ÖZGÜRa, Mahmut YILDIRIMa, Suat ALBAYRAKa, Tuğba YEMİŞa, Semih VANa
aUniversity of Health Sciences, Samsun Training and Research Hospital, Department of Otorhinolaryngology, Samsun, TURKEY
Doi: 10.24179/kbbbbc.2020-75411 - Makale Dili: EN
KBB ve BBC Dergisi. 2020;28(3):203-7
Copyright © 2020 by Turkey Association of Society of Ear Nose Throat and Head Neck Surgery. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Objective: Sudden sensorineural hearing loss (SSNHL) is
defined as hearing loss of at least 30 dB or more in three contiguous frequencies,
occurring within 72 hours. Based on the association of increased
whole blood viscosity (WBV) markers as a prognostic indicator
in vascular disorders, we aimed to determine the association between
whole blood viscosity (WBV) and sudden sensorineural hearing loss
(SSNHL) prognosis. Material and Methods: In this retrospective study,
73 patients diagnosed with SSNHL were included. The WBV calculation
was performed via validated formula by using hematocrit (HCT) and
total plasma protein (TP) concentrations at high shear rate (HSR=208/s)
and the low shear rate (LSR=0.5/s). Pre- and post-treatment pure-tone
average (PTA) results were recorded. In addition mean values of LSR
and HSR were compared between patients and healthy control group.
Results: In the patient group, 54.8% were affected in the right ear and
45.2% in the left ear. Of the patients, 35.6% (n=26) were resistant to
treatment (to Siegel criteria type 4). The higher mean HSR and LSR values
in patients with treatment-resistant and severe SSNHL were not statistically
significant. No statistically significant difference was found
between the patient and control groups according to the WBV values.
Conclusion: Blood viscosity LSR and HSR markers had no predictive
value on SSNHL prognosis. However, it should be considered that direct
measurement of WBV instead of measurement with a formula may
cause different results.
Keywords: Sudden sensorineural hearing loss; whole blood viscosity (WBV); high shear rate (HSR); low shear rate (LSR)
ÖZET
Amaç: Ani işitme kaybı (AİK) 72 saat veya daha kısa sürede aniden
gelişen, ard arda üç frekansta minimum 30 dB veya üzerindeki sensörinöral
işitme kaybıdır (SNİK). Artmış tam kan viskosite (TKV)
markırlarının vaskuler bozukluklarda prognostik bir indikatör olarak ilişkilendirilmesine
dayanarak çalışmamızda AİK tanısı alan hastalarda
TKV'nin prognoza olan etkisinin belirlenmesi amaçlanmıştır. Gereç ve
Yöntemler: Çalışmaya AİK tanısı almış toplam 73 olgu retrospektif olarak
dahil edilmiştir. TKV, hematokrit (HCT) ve total plazma protein (TP)
konsantrasyonları kullanılarak geçerliliği kabul edilmiş formul yardımıyla
düşük (DKH=0.5/s) ve yüksek (YKH=208/s) kesme hızlarında hesaplanmıştır.
Hastalarda tedavi öncesi ve sonrası ölçülen saf ses odyometri sonuçları
ile TKV markırlarının (DKH, YKH) değişimi; karşılaştırılarak
değerlendirildi. Bulgular: Hastaların %54,8’inde sağ kulakta, %45,2’sinde
sol kulakta AİK tanımlanmıştır. Hastaların %35,6 (n=26)’sı tedaviye yanıt
alınamayan (Siegel kriteri tip 4) olarak belirlenmiştir. Tedaviye yanıt alınamayan
ve şiddetli AİK gözlenen gruplarda kan vizkosite ortalama YKH
ve DKH değerlerindeki artış istatistiksel olarak anlamlı bulunmamıştır.
Ayrıca kontrol ve hasta grupları arasında TKV değerleri açısından istatistiksel
olarak anlamlı bir fark belirlenmemiştir. Sonuç: Çalışmamızda formuler
olarak hesaplanan TKV markırlarının AİK prognozunda prediktif
değeri olmadığı sonucuna varılmıştır. İleride daha çeşitli hemotolojik parametreleri
kapsayan ve geniş örneklem grublarından oluşacak çalışmaların,
AİK adına terapötik ve prognostik stratejilerin geliştirilmesi açısından
katkı sağlayacağı kanaatindeyiz.
Anahtar Kelimeler: Ani işitme kaybı (AİK); tam kan viskosite (TKV); yüksek kesme hızı (YKH); düşük kesme hızı (DKH)
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