ORIGINAL RESEARCH
Retrospective Analysis of Histopathological Results of Oral Mucosal Lesions
Oral Mukozal Lezyonlara Ait Histopatolojik Sonuçların Retrospektif Analizi
Received Date : 18 Nov 2021
Accepted Date : 20 Jun 2022
Available Online : 07 Jul 2022
Ceren ERSÖZ ÜNLÜa, Özlem AKKOCAa, Necmi ARSLANa
aDepartment of Otorhinolaryngology, Head and Neck Surgery, University of Health Sciences Ankara Training and Research Hospital, Ankara, Türkiye
Doi: 10.24179/kbbbbc.2021-87082 - Makale Dili: TR
KBB ve BBC Dergisi. 2022;30(3):117-24
Copyright © 2020 by Turkey Association of Society of Ear Nose Throat and Head Neck Surgery. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Objective: The first evaluation according to the morphological
features of the oral mucosal lesion gives us important information
in terms of diagnosis and follow-up, however, the accurate
diagnosis can be made after histopathological examination. In this
study, the histopathological diagnoses of patients who underwent
biopsy for oral mucosal lesions were evaluated. Material and Methods:
The histopathological results of patients who underwent oral mucosal
biopsies between 2009 and 2016 were evaluated according to the
frequency of occurrence, localization, age and gender distribution of
the diagnoses. Lesions were also grouped according to their characteristics
of being benign non-neoplastic, benign neoplastic, premalignant,
and malignant, and data were analyzed within groups. Results: Of the
340 patients, 193 (56.8%) were female and 147 (43.2%) were male.
When the histopathological diagnoses were evaluated according to the
groups, 177 (52.1%) patients had benign non-neoplastic, 126 (37.1%)
patients had benign neoplastic, 14 (4.1%) patients had premalignant,
and 23 (6.8%) patients had malignant lesions. Most of the malignant lesions
were squamous cell carcinoma. The mean age of premalignant
and malignant lesions was found to be significantly higher than the
mean age of patients with benign lesions (p<0.001). Conclusion: Most
of oral mucosal lesions are benign. Although the incidence of premalignant
and malignant lesions increases with age, it should be kept in
mind that they can also be seen in young patients. One of the most important
points in the follow-up of oral mucosal lesions is the timely diagnosis
and treatment of premalignant and malignant lesions.
Keywords: Mouth mucosa; biopsy; pathology; papilloma; squamous cell carcinoma of head and neck
ÖZET
Amaç: Oral mukozal lezyonun morfolojik özelliklerine göre yapılan
ilk değerlendirme bize tanı ve takip açısından önemli bilgi vermektedir,
bununla birlikte kesin tanı alınan biyopsi sonrasında yapılan
histopatolojik inceleme sonucu konabilmektedir. Bu çalışmada, oral mukozal
lezyon nedeniyle biyopsi alınan hastaların histopatolojik tanıları
değerlendirildi. Gereç ve Yöntemler: 2009 ve 2016 yılları arasında oral
mukozadan oral mukozal lezyon nedeniyle biyopsi alınan hastaların histopatoloji
sonuçları tanıların görülme sıklığına, lokalizasyonuna, yaş
ve cinsiyet dağılımlarına göre değerlendirildi. Lezyonlar ayrıca benign
nonneoplazik, benign neoplazik, premalign ve malign lezyon olma
özelliklerine göre gruplandırılarak her grup için veriler incelendi. Bulgular:
Üç yüz kırk hastanın 193’ü (%56,8) kadın, 147’si (%43,2) erkekti.
Histopatolojik tanılar gruplara göre değerlendirildiğinde 177
(%52,1) hastada benign nonneoplazik lezyon, 126 (%37,1) hastada benign
neoplazik lezyon, 14 (%4,1) hastada premalign lezyon ve 23 (%6,8)
hastada malign lezyon izlendi. Malign lezyonların büyük çoğunluğunu
skuamöz hücreli karsinom oluşturmaktaydı. Premalign ve malign lezyonlarda
yaş ortalaması, benign lezyonlara sahip hastaların yaş ortalamasına
göre anlamlı derecede yüksek bulundu (p<0,001). Sonuç: Oral
mukozal lezyonların büyük çoğunluğu benign karakterdedir. Yaşın ilerlemesiyle
premalign ve malign lezyonların görülme sıklığı artmakta, bununla
birlikte genç hastalarda da premalign ve malign lezyonların
görülebileceği akılda tutulmalıdır. Oral mukozal lezyonların takibinde
en önemli noktalardan biri premalign ve malign lezyonların zamanında
tanı konması ve tedavi uygulanmasıdır.
Anahtar Kelimeler: Ağız mukozası; biyopsi; patoloji; papillom; baş ve boyun skuamöz hücreli karsinomu
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