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ORIGINAL RESEARCH

Can We Use Neutrophil: Lymphocyte Ratio, Platelet: Lymphocyte Ratio, and Systemic Immune-Inflammation Index Values to Differentiate Larynx Carcinoma from Benign and Premalignant Laryngeal Diseases in the Elderly?
Yaşlılarda Laringeal Skuamoz Hücreli Karsinomla Benign ve Premalign Laringeal Hastalıkların Ayrımında Nötrofil: Lenfosit Oranı, Trombosit: Lenfosit Oranı ve Sistemik İmmün-İnflamasyon İndeksi Değerlerini Kullanabilir miyiz?
Received Date : 22 Feb 2021
Accepted Date : 14 Mar 2021
Available Online : 18 Mar 2021
Doi: 10.24179/kbbbbc.2021-82505 - Makale Dili: EN
KBB ve BBC Dergisi. 2021;29(3):185-9
Copyright © 2020 by Turkey Association of Society of Ear Nose Throat and Head Neck Surgery. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Objective: Timing for laryngeal biopsy is challenging for geriatric patients due to their comorbidities and anesthetic risks. The aim of this study is to find an indicator that would both allow surgeons to predict the need for laryngeal biopsy, and to diagnose the malignancy at an early stage. Material and Methods: This is a retrospective cohort study of 103 participants. Three groups were constituted according to the results of laryngeal biopsy (benign-Group 1, premalignant-Group 2, and malignant-Group 3). The neutrophil: lymphocyte ratio, the platelet: lymphocyte ratio, and the systemic immune- inflammation index (neutrophil count × platelet count) / lymphocyte count) values of the three groups were compared between groups. Results: The male: female ratio was 100:3, and the mean age was 70.87 (±6.38) years, with no significant differences among the three groups [Group 1: 70.40 (±5.94), Group 2: 70.44 (±5.09), Group 3: 71.15 (±6.91)] (p=0.88). There were no statistically significant differences among the three groups in neutrophil: lymphocyte ratio (p=0.84), platelet: lymphocyte ratio (p=0.36), or systemic immune-inflammation index values (p=0.67). Conclusion: Indices calculated from haematological parameters and showing systemic inflammation may not be reliable in the geriatric population due to immunosenescence. For this reason, indices calculated from haematological parameters should be studied distinctly in the geriatric population without including other age groups. Other methods are needed to help predict the timing of laryngeal biopsy in geriatric patients.
ÖZET
Amaç: Laringeal biyopsi için zamanlamanın planlanması, komorbiditeleri ve anestezi riskleri nedeniyle geriatrik hastalar için zordur. Bu çalışmanın amacı, hem laringeal biyopsi ihtiyacını tahmin etmemize hem de maligniteyi erken dönemde teşhis etmemize olanak sağlayacak bir indeks tespit etmektir. Gereç ve Yöntemler: Bu çalışma, 103 hastayı içeren retrospektif bir kohort çalışmasıdır. Laringeal biyopsi sonuçlarına göre 3 grup oluşturuldu (benign-Grup 1, premalign-Grup 2 ve malign-Grup 3). Üç grubun nötrofil: lenfosit oranı, trombosit: lenfosit oranı ve sistemik immün-inflamasyon indeksi (nötrofil sayısı × platelet sayısı)/lenfosit sayısı) değerleri karşılaştırıldı. Bulgular: Çalışma grubunun erkek: kadın oranı 100: 3 ve ortalama yaşı 70.87 (±6.38) yıl olup, gruplar kıyaslandığında anlamlı bir fark yoktu [Grup 1: 70.40 (±5.94), Grup 2: 70.44 (±5.09), Grup 3: 71.15 (±6.91)] (p=0.88). Üç grup arasında nötrofil: lenfosit oranı (p=0.84), trombosit: lenfosit oranı (p=0.36) ve sistemik immün-inflamasyon indeksi değerleri (p=0.67) arasında istatistiksel olarak anlamlı fark yoktu. Sonuç: Hematolojik parametrelerden hesaplanan ve sistemik inflamasyonu gösteren indeksler immün yaşlanma nedeniyle geriatrik popülasyonda güvenilir olmayabilir. Bu nedenle hematolojik parametrelerden hesaplanan indeksler, geriatrik popülasyonda diğer yaş grupları dâhil edilmeden çalışılmalıdır. Geriatrik hastalarda, laringeal biyopsinin zamanlamasını tahmin etmeye yardımcı olmak için başka yöntemlere ihtiyaç vardır.
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