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ORIGINAL RESEARCH
Comparison of Neutrophil Lymphocyte Ratio in Benign, Premalignant and Malignant Laryngeal Lesions
Benign, Premalign ve Malign Laringeal Lezyonlarda Nötrofil Lenfosit Oranının Karşılaştırılması
Received Date : 24 May 2021
Accepted Date : 09 Nov 2021
Available Online : 16 Oct 2021
Özet PDF Benzer Makaleler
Mustafa ÇOLAKa, Ali Rıza YAĞMURa, Şeyda AKBAL ÇUFALIa, Nagihan GÜLHAN YAŞARa, Aykut İKİNCİOĞULLARIa, Hacı Hüseyin DEREa
aClinic of Otolaryngology, Ankara City Hospital, Ankara, TURKEY
Doi: 10.24179/kbbbbc.2021-84615 - Makale Dili: EN
KBB ve BBC Dergisi. 2022;30(1):1-6
Copyright © 2020 by Turkey Association of Society of Ear Nose Throat and Head Neck Surgery. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
ABSTRACT
Objective: Benign (BG), premalignant (PG) and malignant (MG) lesions can be seen in the laryngeal mucosa. Histopathological examination is absolutely necessary to differentiate these lesions. The ability to differentiate these lesions with inexpensive, easily applicable biomarkers before biopsy can contribute to the planning of the patient’s treatment. The aim of this study is to examine whether neutrophil lymphocyte ratio (NLR) can be used as a biomarker to differentiate MG laryngeal lesions from BG laryngeal lesion and PG laryngeal lesion. Material and Methods: This retrospective study was performed on 72 patients who underwent biopsy to determine their histopathological diagnosis for laryngeal lesions. We analyzed the patient files for clinical, histopathological and laboratory data. The patients were divided into three groups as BG, PG and MG groups according to their histopathological findings. Groups were compared in terms of NLR and other laboratory data. Results: The mean NLR was 2.22±0.61, 2.57±0.8, 3.14±0.91 in the BG, PG and MG, respectively (p=0.001). NLR was higher in MG than BG (p<0.001). NLR values between BG-PG and PG-MG were similar. Conclusion: NLR is higher in MG laryngeal lesions than BG laryngeal lesions. However, NLR is not different from BG and MG lesions in PG laryngeal lesions.
Keywords: Laryngeal carcinoma; benign laryngeal lesions; premalignant laryngeal lesions; neutrophil lymphocyte ratio
ÖZET
Amaç: Laringeal mukozada benign (BG), premalign (PG) ve malign (MG) lezyonlar görülebilir. Bu lezyonların ayrımında mutlaka histopatolojik inceleme gereklidir. Biyopsi öncesinde bu lezyonların ucuz, kolay uygulanabilir biyobelirteçlerle ayırt edilebilmesi, hastanın tedavisinin planlanmasına katkıda bulunabilir. Bu çalışmanın amacı, nötrofil lenfosit oranının (NLO) MG laringeal lezyonları, BG laringeal lezyonlardan ve PG laringeal lezyonlardan ayırt etmek için bir biyobelirteç olarak kullanılıp kullanılamayacağını incelemektir. Gereç ve Yöntemler: Bu retrospektif çalışma, larenks lezyonlarının histopatolojik tanısını belirlemek için biyopsi yapılan 72 hasta üzerinde gerçekleştirildi. Hasta dosyaları klinik, histopatolojik ve laboratuvar verileri için analiz edildi. Hastalar histopatolojik bulgularına göre BG, PG ve MG olarak 3 gruba ayrıldı. Gruplar NLO ve diğer laboratuvar verileri açısından karşılaştırıldı. Bulgular: Ortalama NLO, BG, PG ve MG’de sırasıyla 2,22±0,61, 2,57±0,8, 3,14±0,91 idi (p=0,001). MG’de NLO, BG’den daha yüksekti (p<0,001). BG-PG ve PG-MG arasındaki NLO değerleri benzerdi. Sonuç: NLO, MG laringeal lezyonlarda BG laringeal lezyonlardan daha yüksektir. Ancak NLO, PG laringeal lezyonlarda BG ve MG lezyonlardan farklı değildir.
Anahtar Kelimeler: Larinks kanseri; benign larinks lezyonları; premalign larinks lezyonları; nötrofil lenfosit oranı
KAYNAKLAR
  1. Vasconcelos D, Gomes AOC, Araújo CMT. Vocal fold polyps: literature review. Int Arch Otorhinolaryngol. 2019;23(1):116-24. [Crossref]  [PubMed]  [PMC] 
  2. Nocini R, Molteni G, Mattiuzzi C, Lippi G. Updates on larynx cancer epidemiology. Chin J Cancer Res. 2020;32(1):18-25. [Crossref]  [PubMed]  [PMC] 
  3. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67(1):7-30. [Crossref]  [PubMed] 
  4. van Hulst AM, Kroon W, van der Linden ES, Nagtzaam L, Ottenhof SR, Wegner I, et al. Grade of dysplasia and malignant transformation in adults with premalignant laryngeal lesions. Head Neck. 2016;38 Suppl 1:E2284-90. [Crossref]  [PubMed] 
  5. Davaris N, Voigt-Zimmermann S, Kropf S, Arens C. Flexible transnasal endoscopy with white light or narrow band imaging for the diagnosis of laryngeal malignancy: diagnostic value, observer variability and influence of previous laryngeal surgery. Eur Arch Otorhinolaryngol. 2019;276(2):459-66. [Crossref]  [PubMed]  [PMC] 
  6. Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS, Pujari VB. Inflammation and cancer. Ann Afr Med. 2019;18(3):121-6. [Crossref]  [PubMed]  [PMC] 
  7. Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol. 2013; 88(1):218-30. [Crossref]  [PubMed] 
  8. Cupp MA, Cariolou M, Tzoulaki I, Aune D, Evangelou E, Berlanga-Taylor AJ. Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies. BMC Med. 2020;18(1):360. [Crossref]  [PubMed]  [PMC] 
  9. Howard R, Kanetsky PA, Egan KM. Exploring the prognostic value of the neutrophil-to-lymphocyte ratio in cancer. Sci Rep. 2019;9(1): 19673. [Crossref]  [PubMed]  [PMC] 
  10. Bulgurcu S, Arslan İB, Dikilitaş B, Çukurova İ. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in malignant and precancerous laryngeal lesions. Turkish J Ear Nose Throat. 2017;27(3): 122-7. [Link] 
  11. Kum RO, Ozcan M, Baklaci D, Kum NY, Yilmaz YF, Gungor V, et al. Elevated neutrophil-to-lymphocyte ra tio in squamous cell car cinoma of larynx compared to benign and precancerous laryngeal lesions. Asian Pac J Cancer Prev. 2014;15(17):7351-5. [Crossref]  [PubMed] 
  12. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860-7. [Crossref]  [PubMed]  [PMC] 
  13. David JM, Dominguez C, Hamilton DH, Palena C. The IL-8/IL-8R axis: a double agent in tumor immune resistance. Vaccines (Basel). 2016;4(3):22. [Crossref]  [PubMed]  [PMC] 
  14. Shaul ME, Fridlender ZG. Tumour-associated neutrophils in patients with cancer. Nat Rev Clin Oncol. 2019;16(10):601-20. [Crossref]  [PubMed] 
  15. Wislez M, Rabbe N, Marchal J, Milleron B, Crestani B, Mayaud C, et al. Hepatocyte growth factor production by neutrophils infiltrating bronchioloalveolar subtype pulmonary adenocarcinoma: role in tumor progression and death. Cancer Res. 2003;63(6): 1405-12. [PubMed] 
  16. Schmidt H, Bastholt L, Geertsen P, Christensen IJ, Larsen S, Gehl J, et al. Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model. Br J Cancer. 2005;9 3(3):273-8. [Crossref]  [PubMed]  [PMC] 
  17. Trellakis S, Bruderek K, Dumitru CA, Gholaman H, Gu X, Bankfalvi A, et al. Polymorphonuclear granulocytes in human head and neck cancer: enhanced inflammatory activity, modulation by cancer cells and expansion in advanced disease. Int J Cancer. 2011;129(9):2183-93. [Crossref]  [PubMed] 
  18. Shau HY, Kim A. Suppression of lymphokine-activated killer induction by neutrophils. J Immunol. 1988;141(12):4395-402. [PubMed] 
  19. Zhao J, Huang W, Wu Y, Luo Y, Wu B, Cheng J, et al. Prognostic role of pretreatment blood lymphocyte count in patients with solid tumors: a systematic review and meta-analysis. Cancer Cell Int. 2020;20:15. [Crossref]  [PubMed]  [PMC] 
  20. Mascarella MA, Mannard E, Silva SD, Zeitouni A. Neutrophil-to-lymphocyte ratio in head and neck cancer prognosis: a systematic review and meta-analysis. Head Neck. 2018;40(5):1091-100. [Crossref]  [PubMed] 
  21. Yang F, Huang Q, Guan Z, Diao Q. Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in patients with laryngeal cancer: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2021;278(2):417-25. [Crossref]  [PubMed] 
  22. Wu DQ, Huang XS. [The significance of lymphocyte to monocyte ratio in peripheral blood of patients with benign and malignant laryngeal lesions]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017; 31(11): 835-8. [PubMed] 
  23. Eskiizmir G, Uz U, Onur E, Ozyurt B, Karaca Cikrikci G, Sahin N, et al. The evaluation of pretreatment neutrophil-lymphocyte ratio and derived neutrophil-lymphocyte ratio in patients with laryngeal neoplasms. Braz J Otorhinolaryngol. 2019;85(5):578-87. [Crossref]  [PubMed] 
  24. Duzlu M, Karamert R, Tutar H, Karaloglu F, Sahin M, Cevizci R. Neutrophil-lymphocyte ratio findings and larynx carcinoma: a preliminary study in Turkey. Asian Pac J Cancer Prev. 2015;16(1):351-4. [Crossref]  [PubMed] 
  25. Kara A, Guven M, Demir D, Yilmaz MS, Gundogan ME, Genc S. Are calculated ratios and red blood cell and platelet distribution width really important for the laryngeal cancer and precancerous larynx lesions. Niger J Clin Pract. 2019;22(5):701-6. [PubMed] 
  26. Yılmaz B, Şengül E, Gül A, Alabalık U, Özkurt FE, Akdağ M, et al. Neutrophil-lymphocyte ratio as a prognostic factor in laryngeal carcinoma. Indian J Otolaryngol Head Neck Surg. 2018;70(2):175-9. [Crossref]  [PubMed]  [PMC] 
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